Curing Cancer With Repurposed Drugs

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The following article was published yesterday by Dr. Justus R. Hope. Please subscribe to his substack, justusrhope.substack.com, for more lifesaving information that he publishes.

Riggins’ Mice and Curing Cancer

Many terminal cancer patients have survived and even been cured by adding repurposed drugs.  Repurposed drugs are those deemed safe and effective by the FDA for treating other conditions, like worms or parasites – drugs like Mebendazole or Ivermectin.

Leading cancer researchers at prestigious institutions are now beginning to find that such repurposed drugs can help prevent cancer spread – known as metastasis – which is the ultimate cause of death in most cancer patients. For example, consider this quote from Dr. Gregory Riggins of the Johns Hopkins University School of Medicine.

“We are building on our recent findings that already approved and a relatively non-toxic drug can slow early pancreatic cancer growth and prevent metastasis. Coupled with early detection- this inexpensive drug could save lives. Currently trying to identify a postdoc to spearhead this work.”

Riggins was referring to Mebendazole in his Linkedin post.

Dr. Riggins is the researcher whose test mice with implanted brain cancer developed pinworms. He treated them with Fenbendazole, which killed the worms but curiously also killed their cancers. Thus began his research into the related human drug, Mebendazole, which has shown a massive effect against human cancers, especially against Glioblastoma, the kind my friend Evan has.

Evan has been on a repurposed drug cocktail, including Mebendazole since his brain cancer was found some four years ago.

Despite being given only an average of one year to live, he remains alive and well today. Only about 1% of GBM patients survive their cancers more than two years, and Evan now enjoys being called a long-term survivor.

But as the mainstream media like Yahoo would lead you to believe, is this just a coincidence, or is there a real benefit of taking drugs like Ivermectin and Mebendazole as adjunctive treatment with cancer?

The mainstream media and Big Pharma would prefer you limit your treatment options to expensive and patented new drugs. In contrast, the studies and reports on repurposed drugs suggest they be added for maximum survival.

The published studies in PubMed, the National Library of Medicine, strongly support these repurposed drugs' effect on known cancer signaling and genetic pathways. Beyond that is clinical evidence of benefit. Finally, these drugs are infinitely safer and better tolerated than most toxic chemotherapy agents, which can produce bone marrow suppression, cardiac toxicity, and fatal illness by themselves, never mind cancer.

Consider this clinical trial, METRIC, which used a cocktail of four repurposed drugs, including Mebendazole, to treat GBM. Those patients who received the standard surgery, radiation, and chemotherapy treatment lived an average of 12.7 months, while those on the METRIC cocktail survived an average of 27.1 months, more than double.

Beyond that are case reports of long-term remission. 

Few are more famous than the case of Joe Tippens. Joe’s life was going well at the time, immediately before his terrible diagnosis. Tippens was all set to accept a lucrative partnership position in Switzerland when a physician discovered a considerable growth in his left lung [02:10].

“So I picked up the phone and called Switzerland, canceled my trip, canceled my acceptance of that job, and started my journey with MD Anderson (Cancer Center) in Houston, Texas. Through a comedy of errors that weren’t their fault – I got pneumonia along the way, and they had to change the regimen and double up the radiation – they fried my esophagus into bacon when nothing would go down. And instead of doing a feeding tube, I decided to live off my fat and muscle stores, and I went eight weeks with no nutrients in my body – zero [03:03].”

Three months following his diagnosis of Small Cell Carcinoma of the Lung, it had metastasized or spread throughout his body – “from head to toe.”

“I had tumors in my neck, stomach, bladder, pancreas, and bones from head to toe [03:55]. I don’t know if your listeners know, but when you have small cell cancer that has metastasized that far afield, you’re basically a goner – the life expectancy goes below 1%. The median life expectancy is around three months [04:18].”

Joe Tippens was told to hire hospice and get his affairs in order – essentially to get ready to die.

After he told his friends and family the dire news, an old college friend – a large animal veterinarian told him about the mice and suggested he might take Fenbendazole, the veterinary version of Mebendazole. In addition, Tippens did his research and wisely added bioavailable Curcumin. As it turns out, much data mechanistically supports the anti-cancer action of Curcumin.

As Dr. Paul Marik has found, “Curcumin has an impact on the tumor microenvironment by inhibiting angiogenesis even under the hypoxic status within the tumor microenvironment. [1] Furthermore, curcumin has activity against cancer stem cells in addition to promoting apoptosis. [1,3,4] Curcumin induces apoptosis in tumor cells,[2] through ROS-mediated endoplasmic reticulum (ER) stress and mitochondrion-dependent pathways.[1] In addition, curcumin acts through the Wnt/-catenin pathway. [5]”       

He threw in CBD oil and Vitamin E for good measure. Then he waited. As Tippens explains it, “I went through a period of unknown. I went all the way through January, February, March and April of 2017 waiting to die because the median life expectancy was three months, but I felt fine - there were no symptoms, I felt great, I was working again, and I went in for a scan the first week of May of 2017 – 3 ½ months later and I was all clear [08:03]. A previous PET scan that lit up like a Christmas Tree from my neck to my pelvis in my bones and all my internal organs was now gone – completely.”

Tippens's answer was revealing when asked what his physician's take was. “There’s the private physician that you’ve become a friend with behind the closed door, [10:05] and there’s the public physician who represents a major cancer hospital – the private guy and the public guy are two separate things, right? So I think behind closed doors, he basically says, "okay, I admit what you did had an impact, but publicly as an institution, you can’t make that statement.”

Joe admits he was also involved in a clinical trial at the time with the testing of a new drug; however, he reports that out of all those in the trial, he was the only patient who achieved total remission, so he does not believe the experimental drug had anything to do with his success [10:59]. He reports that because he has heard a hundred other success stories involving cancers of all different types and stages, he is even more convinced. His method has become known worldwide as the Tippens Protocol, and he admits the attention with 20 or 30 telephone calls a day was difficult as it took time away from his career [11:36]. To save himself the time to retell his story to each caller, he wrote a blog that he could refer them to read. After publishing, he was surprised to watch his blog go viral. He then set up a discussion group on Facebook entitled “My Cancer Rocks”, which also went viral. He found himself having to engage volunteer moderators at that point because addressing the posts was a full-time job.

“We are limiting that Facebook page to only cancer patients and caregivers – anybody can get in there. And we’re limiting it to the protocol discussion that saved me and 100 other people [12:51].”

Additionally, Joe remarks that a graduate student in Arizona has translated his blog into Chinese, and it has become extremely popular with people in China. Reports have estimated 3 ½ million hits on his Chinese Blog, with some 30 to 50 thousand on the protocol in China [13:56].

Why does it work? As Dr. Riggins has published, one reason is that Fenbendazole and Mebendazole inhibit microtubule assembly in dividing cancer cells. Another is that it blocks both the TGF-Betaand the Hedgehog Signaling Pathway involved in metastasis and cancer stem cell stimulation.

Cancer stem cells are essentially the microscopic roots of cancer, and they are stimulated whenever the bulk of the tumor is attacked, whether by surgery, radiation, or chemicals – chemotherapy. These signals to the cancer stem cells are transmitted by three or four signaling pathways, including the WnT, the Notch, the Hedgehog, and TGF-Beta. Repurposed drugs like Ivermectin, Fenbendazole, and Mebendazole all inhibit one or more of these signaling pathways, thereby suppressing the spread and regrowth of the tumor.

In my opinion, this is the best reason all cancer patients should consider – with the blessing of a personal physician, of course - adding repurposed drug cocktails designed to block metastasis and regrowth of cancer. It is not enough to treat cancer with the standard of care because the standard produces poor results. It is essential to suppress cancer stem cell growth at the beginning of cancer treatment.

Adding repurposed drugs like the antiparasitics and supplements like Curcumin, Vitamin D3, and Vitamin E can do this. For additional information, the reader is referred to my book on repurposed drugs. In addition, the FLCCC is finalizing a Monograph summarizing the current science on repurposed drugs and cancer.

1.     Xiang DB, Zhang KQ, Zeng YL et al. Curcumin: From a controversial "panacea" to effective antineoplastic products. Medicine (Baltimore) 2020; 99:e18467.

2.     Pal S, Bhattacharyya S, Choudhuri T et al. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detect Prev 2005; 29:470-478.

      3.   Ye MX, Li Y, Yin H et al. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. Int J Mol Sci 2012; 13:3959-78.

      4.   Li Y, Zhang T. Targeting cancer stem cells by curcumin and clinical applications. Cancer Lett 2014; 346:197-205.

      5.   Zoi V, Galani V, Lianos GD et al. The Role of Curcumin in Cancer Treatment. Biomedicines 2021; 9.

Please see Dr. Justus R. Hope’s original article link below, and subscribe to his lifesaving work.

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Riggins’ Mice and Curing Cancer